细胞质膜微囊-微囊蛋白及其相关信号分子

信号转导是近年来细胞生物学研究十分活跃的领域。这种信号转导过程主要是在生物膜上进行的 ,而究竟是在生物膜的什么部位 ,一直是大家关注的问题。细胞质膜微囊 (ｃａｖｅｏｌａｅ,ｃｌｅ)和微囊蛋白(ｃａｖｅｏｌｉｎ ,ｃｌｎ)的发现为研究信号转导提供了一个重要线索。随着研究的不断深入 ,尤其是实验方法的不断成熟从而能够大量获取ｃｌｅ这一特异性质膜以及对其包被蛋白质ｃｌｎ认识增加 ,人们逐渐认识到ｃｌｅ是细胞信号转导和加工中心 ,在基础状态或膜表面特异性受体激活状态下 ,与信号转导有关的受体、激酶、联接蛋白等在ｃｌｅ膜区…

Caveolae-caveolin and associated signaling molecules

Caveolae, specialized vesicular invaginations of the plasma membrane ,have attracted increasing attentions to those who are studing siginal transduction .Many proteins involved in signal transduction have been found enriched in these microdomains.Caveolins,as marker proteins of caveolae,form a scaffold onto which many classes of signaling molecules can assemble at steady state or after ligand-induced activiton .In addition to concentrating these signal transducers within a distinct region of the plasma membrane ,caveolin binding may functionally regulate the activation state of caveolae-associated signaling molecules.Thus,an emerging notion is that caveolae are signaling processing centers which orchestrate signaling events at the cell surface that influence cell function .