Formation of immune (gamma) interferon induced by staphylococcal enterotoxin and phytohemagglutinin

Some conditions of production of human and mouse immune interferon induced by phytohemagglutinin and a national preparation of staphylococcal enterotoxin A (SEA) were studied. The latter was shown to be suitable for use as an inducer of this type of interferon. Production of mouse immune interferon could be increased by using a mixture of spleen and peritoneal exudate cells. Interferon production induced by SEA was also higher in spleen cells of mice immunized with BCG.