实验性前部PVR血-房水屏障的改变

目的 通过房水蛋白浓度的测定,探讨实验性前部增生性玻璃体视网膜病变（anterior proliferative vitreoretinopathy,aPVR）病理状态下血－房水屏障的变化。方法 将培养的同种兔皮肤成纤维细胞10^5注入行睫状体平部穿通伤及晶状体切除后的兔眼睫状前区，制作前部PVR的动物模型，以行睫状体平部穿通伤及晶状体切除后的兔眼作为对照组，以不做手术的兔眼为正常组。于术后14、28、56d分别测定实验组和对照组房水蛋白的含量。结果 术后2周，实验组和对照组房水蛋白含量无明显差别，但均明显高于正常组；术后4周、8周实验组房水蛋白含量明显于对照组。结论 在aPVR病理状态下，血－房水屏障受到破坏，是引起低眼压的原因之一。

The changes of blood-aqueous humor barrier in experimental anterior proliferative vitreoretinopathy

Objective To test the concentration of protein in the aqueous humor,and to realize the changes of blood aqueous humor barrier in experimental anterior proliferative vitreoretinopathy(aPVR).Methods Pars plana perforation injury,pars plana lensectomy were performed on pigmented rabbits and 10 5 cultured homologous rabbit dermal fibroblasts were injected over the epiciliary area.As control,pars plana perforation injury and lensectomy were performed on pigmented rabbits without injection fibroblasts.Pigmented rabbits without any operattions were treated as normal group.14th,28th,56th day postoperately,the concentration of protein in the aqueous humor was tested .Results Two weeks postoperatively,the concentration of protein in the aqueous humor in experimental and control groups were similar,but both of them were more than that in normal group remarkably.Conclusion The blood aqueous humor barrier in aPVR was broken and it was one of the reasons of hypotony following aPVR.