Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program |
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| Authors: | Email author" target="_blank">Lisa?CegliaEmail author Jason?Nelson James?Ware Konstantinos-Dionysios?Alysandratos George?A?Bray Cheryl?Garganta David?M?Nathan Frank?B?Hu Bess?Dawson-Hughes Anastassios?G?Pittas Diabetes Prevention Program Research Group |
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| Institution: | 1.Division of Endocrinology,Diabetes and Metabolism, Tufts Medical Center,Boston,USA;2.Institute for Clinical Research and Health Policy Studies,Tufts Medical Center,Boston,USA;3.Department of Biostatistics,Harvard School of Public Health,Boston,USA;4.Pennington Biomedical Research Center,Louisiana State University,Baton Rouge,USA;5.Department of Pathology, Immunology and Laboratory Medicine,University of Florida,Gainsville,USA;6.Diabetes Center,Massachusetts General Hospital and Harvard Medical School,Boston,USA;7.Departments of Nutrition and Epidemiology,Harvard School of Public Health,Boston,USA;8.Channing Laboratory,Brigham and Women’s Hospital,Boston,USA;9.Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging,Tufts University,Boston,USA;10.Division of Neurology,Boston University Medical Center,Boston,USA |
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| Abstract: | ObjectiveWe examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.MethodsThe study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.ResultsIn cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % 95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.ConclusionOur study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive. |
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