Comparison of endoscopic findings with symptom assessment systems (FSSG and QUEST) for gastroesophageal reflux disease in Japanese centres |
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| Authors: | Akiko Danjo Kanako Yamaguchi Kazuma Fujimoto Toshihito Saitoh Masahiko Inamori Takashi Ando Tomohiko Shimatani Kyoichi Adachi Fukunori Kinjo Shiko Kuribayashi Shoji Mitsufuji Yasuhiro Fujiwara Shigeki Koyama Junichi Akiyama Atsushi Takagi Noriaki Manabe Hiroto Miwa Yasuyuki Shimoyama Motoyasu Kusano |
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| Institution: | 1. Department of Internal Medicine, Saga Medical School, Saga,;2. Department of Internal Medicine, Tokyo Women's Medical University Medical Center East, Tokyo,;3. Department of Gastroenterology, Yokohama City University Hospital, Yokohama,;4. Department of Gastroenterology, Social Insurance Kyoto Hospital, Kyoto,;5. Department of General Medicine, Hiroshima University Hospital, Hiroshima,;6. Department of Clinical Nursing, Faculty of Medicine, Shimane University, Shimane,;7. Department of Endoscopy, University Hospital, University of the Ryukyus, Okinawa,;8. Department of Internal Medicine, National Hospital Organization Numata National Hospital, Gunma,;9. Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto,;10. Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka,;11. Department of Gastroenterology, Kusatsu General Hospital, Gunma,;12. Department of Gastroenterology, International Medical Center of Japan, Tokyo,;13. Department of Internal Medicine, Tokai University School of Medicine, Kanagawa,;14. Division of Endoscopy and Ultrasonography, Kawasaki Medical School, Okayama,;15. Department of Upper Gastroenterology, Hyogo College of Medicine, Hyogo,;16. Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan |
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| Abstract: | Background and Aim: We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis. Methods: We registered 475 patients with untreated symptoms of upper abdominal pain (male/female: 252/223, average age 52.4 ± 17.8 years). Subjects were assessed first with the FSSG and QUEST questionnaires, then by endoscopy, before allocation to a gastric ulcer (GU), duodenal ulcer (DU), gastroesophageal reflux disease (GERD) or functional dyspepsia (FD) group. Results: On the basis of the endoscopic findings the diagnoses for the 475 subjects were as follows: FD 52.2%, DU 7.6%, GU 7.8%, and GERD 32.4% (Grade M 10.1%, Grade A + B 20.2%, Grade C + D 2.3%). There was no difference between the FSSG and QUEST in sensitivity, specificity or accuracy for any condition. The FSSG score rose with increasing endoscopic severity of GERD, but there was no correlation between the QUEST score and endoscopic severity. The FSSG total score was inferior to QUEST in terms of distinguishing GERD from other conditions, but when only the questions relating to reflux symptoms were used, the FSSG was able to distinguish GERD from other conditions as well as QUEST. Conclusions: The FSSG score reflects the severity of the endoscopic findings of GERD. |
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| Keywords: | clinical symptoms endoscopy heartburn Los Angeles Classification proton‐pump inhibitor |
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