首页 | 本学科首页   官方微博 | 高级检索  
     


Cumulative radiation dose after lung transplantation in patients with cystic fibrosis
Authors:I. Fitton  M.-P. Revel  P.-R. Burgel  A. Hernigou  V. Boussaud  R. Guillemain  F. Le Pimpec-Barthes  S. Bennani  G. Freche  G. Frija  G. Chassagnon
Affiliation:1. Radiology Department, Hôpital Européen Georges-Pompidou, Université Paris 5-Descartes, 20, rue Leblanc, 75015 Paris, France;2. Radiology Department, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Université Paris 5-Descartes, 27, rue du faubourg Saint-Jacques, 75014 Paris, France;3. Pulmonary Department and Adult CF Center, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Université Paris 5-Descartes, 27, rue du faubourg Saint-Jacques, 75014 Paris, France;4. Department of Cardiovascular Surgery and Organ Transplantation, Hôpital Européen Georges-Pompidou, Université Paris 5- Descartes, 20, rue Leblanc, 75015 Paris, France;5. Department of Thoracic surgery, Hôpital Européen Georges-Pompidou, Université Paris 5-Descartes, 20, rue Leblanc, 75015 Paris, France
Abstract:

Purpose

The purpose of this study was first to evaluate the imaging-related cumulative post-transplantation radiation dose in cystic fibrosis (CF) lung transplantation (LT) recipients and second, to identify the occurrence and type of malignancies observed after LT.

Materials and methods

A total of 52 patients with CF who underwent LT at our institution between January 2001 and December 2006 with at least 3 years of survival were retrospectively included. There were 27 men and 25 women with a mean age of 24.4 ± 9.2 (SD) years (range: 7.6–52.9 years) at the time of LT. Calculation of cumulative effective and organ doses after LT were based on dosimetry information and acquisition parameters of each examination. Cumulative radiation doses were calculated until June 2016, but stopped at the time of de novomalignancy diagnosis, for patients developing the condition.

Results

Patients received a mean cumulative effective dose of 110.0 ± 51.6 (SD) mSv (range: 13–261.3 mSv) over a mean follow-up of 8.1 ± 3.6 (SD) years (range: 0.5–13.5 years), with more than 100mSv in 5 years in 19/52 patients (37%). Chest CT accounted for 73% of the cumulative effective dose. Mean doses to the lung, breast and thyroid were 152.8 ± 61.1 (SD) mGy (range: 21.2–331.6 mGy), 106.5 ± 43.2 (SD) mGy (range: 11.9–221.4 mGy) and 72.7 ± 31.8 (SD) mGy (range: 9.5–165.0 mGy), respectively. Nine out of 52 patients (17%) developed a total of 10 de novo malignancies, all but one attributable to immunosuppression after a mean post-transplantation follow-up period of 11.1 ± 3.5 (SD) years (range: 3.7–16.3 years). Six-month cumulative effective dose was not greater in patients with de novomalignancies than in those without de novomalignancies (28.9 ± 14.5 (SD) mGy (range: 13.0–53.4) vs 25.6 ± 15.3 (range: 5.0–69.7), respectively, P > 0.05).

Conclusion

The cumulative effective dose exceeded 100 mSv in 5 years in 37% of LT recipients, the reason why continuous efforts should be made to optimize chest CT acquisitions accounting for 73% of the radiation dose.
Keywords:Cystic fibrosis  Radiation exposure  Lung transplantation  Effective dose
本文献已被 ScienceDirect 等数据库收录！
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号