| Affiliation: | 1.Academic Unit of Surgery, College of Medical, Veterinary and Life of Sciences, Royal Infirmary,University of Glasgow,Glasgow,UK;2.University Departments of Pathology, Faculty of Veterinary Medicine, Omar Almukhtar University,Al bayda,Libya;3.Unit of Experimental Therapeutics, Institute of Cancer, College of Medical, Veterinary and Life Sciences, Royal and Western Infirmary,University of Glasgow,Glasgow,UK;4.University Department of Pathology, College of Medical, Veterinary and Life of Sciences, Royal and Western Infirmaries, University of Glasgow,Glasgow,UK;5.Department of Surgery,Western Infirmary,Glasgow,UK |
| Abstract: | BackgroundSeveral well-established tumour prognostic factors are used to guide the clinical management of patients with breast cancer. Lymphovascular invasion and angiogenesis have also been reported to have some promise as prognostic factors. The aim of the present study was to examine the prognostic value of tumour lymphovascular invasion and microvessel density compared with that of established prognostic factors in invasive ductal breast cancer.MethodsIn addition to hormone receptor status and Ki-67 proliferative activity, lymphovascular invasion and microvessel density and their relationship with survival were examined in patients with invasive ductal breast cancer. Full sections and tissue microarrays (n?=?384 patients) were utilised to assess these factors and were scored by appropriate methods.ResultsOn univariate analysis tumour size ( P?P?P?P?P?P?P?P?P?P?P?P?P?P? ConclusionLymphovascular invasion but not microvessel density was independently associated with poorer survival in patients with ER positive but not ER negative invasive ductal breast cancer. |
