| TLR-9基因多态性与系统性红斑狼疮的相关性研究 |
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| 引用本文： | 宋璇,宋卫青. TLR-9基因多态性与系统性红斑狼疮的相关性研究[J]. 医学检验与临床, 2011, 22(2): 19-21,12. DOI: 10.3969/j.issn.1673-5013.2011.02.007 |
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| 作者姓名： | 宋璇 宋卫青 |
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| 作者单位： | 1. 青岛大学医学院在职硕士研究生,山东青岛,266021;青岛市市立医院检验科,山东青岛,266011
2. 青岛市市立医院检验科,山东青岛,266011 |
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| 摘 要： | 目的 分析山东地区汉族人群TLR-9基因rs187084、rs352139等位点的多态性,探讨其与系统性红斑狼疮的相关性.方法 采用PCR-RFLP等方法对92例系统性红斑狼疮患者和88例健康对照者TLR-9 基因rs187084、rs352139的多态性进行分析,计算基因型和等位基因频率结果：SLE患者TLR-9基因rs187084CC、CT、TT基因型频率分别是0.185、0.413和0.402,rs352139AA、AG、GG基因型频率分别是0.228、0.533和0.239,与对照组间差异没有统计学意义（χ2=2.99,P〉0.05,χ2=4.54,P〉0.05）.结论 TLR-9基因可能在SLE发病中起一定作用.
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| 关 键 词： | 系统性红斑狼疮 TLR-9 单核苷酸多态性 |
Relativity study between TLR-9 gene polymorphism and SLE |
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| Song Xuan,Song Weiqing. Relativity study between TLR-9 gene polymorphism and SLE[J]. Medical Laboratory Science and, 2011, 22(2): 19-21,12. DOI: 10.3969/j.issn.1673-5013.2011.02.007 |
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| Authors: | Song Xuan Song Weiqing |
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| Affiliation: | Song Xuan,Song Weiqing (Medical college of Qingdao university, Qingdao, 266021 ) |
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| Abstract: | Objective To investigate two single nucleotide polymorphism sites of TLR- 9 and to detect their relationship with SLE. Methods The polymorphisms were detected with PCR - RFLP in 92cases of SLE and 88 healthy controls; The genotype and allele frequencies were calculated and analyzed. Results The genotype frequencies of CC, CT and TT in rs187084 site in SLE were 0.185, 0.413 and 0.402 respectively; and that of AA, AG and GG in rs352139 site were 0.228, 0.533 and 0.239 respectively （x^2 = 2.99, p 〉 0.05; x^2 ： 4.54, p 〉 0. 05）. Conch.talon Abnormal expression of TLR - 9 may play certain role in the pathogenesis of SLE. |
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| Keywords: | TLR-9 |
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