| 基质金属蛋白酶家族与肿瘤转移 |
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| 引用本文： | 曹士德,宋云霄. 基质金属蛋白酶家族与肿瘤转移[J]. 中国当代医药, 2011, 18(13): 15-16,20 |
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| 作者姓名： | 曹士德 宋云霄 |
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| 作者单位： | 上海市徐汇中心医院检验科,上海,200031 |
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| 摘 要： | 基质金属蛋白酶家族（MMPs）是一种由二十多个成员组成的大家族,因其依赖于金属离子作为辅助因子而得名。MMPs能降解细胞外基质中的各种物质并且在许多肿瘤中呈现高相关性。MMPs在肿瘤转移中的多个环节高表达,因此关于MMPs与肿瘤转移方面的研究成果对于人们认识肿瘤以及肿瘤治疗都有极其重大的意义。
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| 关 键 词： | 基质金属蛋白酶 肿瘤转移 金属离子 肿瘤治疗 |
Matrix metalloproteinases and tumor metastasis |
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| CAO Shide,SONG Yunxiao. Matrix metalloproteinases and tumor metastasis[J]. http://www.botanicus.org/, 2011, 18(13): 15-16,20 |
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| Authors: | CAO Shide SONG Yunxiao |
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| Affiliation: | Department of Laboratory,Shanghai Xuhui Central Hospital,Shanghai 200031,China |
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| Abstract: | Matrix metalloproteinases（MMPs） is a big family with more than twenty members.They are named after their metal-ion cofactors.MMPs can degrade a variety of proteins in extracellular matrixc（ECM） and they are related to most neoplasms.The expression levels of MMPs are very high in the overall process of the metastasis,so the studies on both MMPs and metastasis are very valuable for people to be more aware of neoplasm and to cure neoplasm. |
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| Keywords: | Matrix metalloproteinase Tumor metastasis Metal ions Cancer therapy |
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