厄贝沙坦对高血压患者纤溶活性内皮素一氧化氮降钙素基因相关肽的影响

目的　观察厄贝沙坦治疗原发性高血压(EH)时对纤溶活性、内皮素(ET)、一氧化氮(NO)、降钙素基因相关肽(CGRP)的影响。方法　6 2例健康体检者作为正常对照组,6 8例EH患者用厄贝沙坦治疗8周,观察用药前后血压、血浆组织型纤溶酶原激活物(t -PA)及其抑制物(PAI)活性及内皮素、一氧化氮、降钙素基因相关肽浓度的变化。结果　EH患者t PA活性、CGRP和NO浓度明显低于正常对照组(P <0 .0 1) ;而PAI活性、ET浓度明显高于正常对照组(P <0 .0 1) ,厄贝沙坦治疗后,血压显著低于治疗前(P <0 .0 1) ,血t -PA活性、NO、CGRP浓度均较治疗前显著升高(P <0 .0 1) ;血ET浓度显著下降(P <0 .0 1)。结论　EH患者存在纤溶活性和内皮功能异常;厄贝沙坦可改善EH患者纤溶活性和内皮功能。

The effects of irbesartan on fibrinolytic activity, endothelin, nitric oxide and calaitonin gene related peptide in patients with essential hypertension

Objective To investigate effe ct s of irbesartan on fibrinolytic activity,endothelin,nitric oxide and calaitonin gene related peptide in patients with essential hypertension.Methods Sixty-two healths were assigned as normal control group,sixty-eight pat ients with essential hypertension were treated with irbesartan for 8 weeks,blood pressure,plasma activity of tissue-type plasminogen activator (t-PA),plasmino gen activator inhibitor (PAI) and plasma concentration of endothelin(ET),nitric oxide (NO) and calaitonin gene related peptide (CGRP) were measured before and 8 weeks after the treatment.Results Plasma activity of t-PA an d plasma concentration of NO,CGRP in patients with essential hypertension were s inificantly lower than those in normal control group(P<0.01),plasma activ ity of PAI and plasma concentration of ET in patients with essential hypertensio n were remarkly hihger than those in normal control group(P<0.01).after irbesartan teratment,Blood pressure was significantly reduced (P<0.0 1),plasma activity of t-PA and plasma concentration of NO,CGRP were siginifica ntly elevated (P<0.01),plasma activity of PAI and plasma concentration of ET were were remarkly decreased(P<0.01).Conclusions The plasma activity of t-PA,PAI and plasma concentration of ET,NO,CGRP are abnorma l in patients with essential hypertension.The irbesartan can improve fibrinolyti c activity and endothelial function in patienta with essential hypertension.