应用对比经颅多普勒技术评价偏头痛和卵圆孔未闭的关系

目的：观察门诊有先兆偏头痛（MA），无先兆偏头痛（M0）患者和无头痛人群中卵圆孔未闭（PFO）的发生率，以及产生中或大分流PFO的发生率。方法：经受试者同意后，随机抽取我院神经内科门诊从2006年3月至2007年3月就诊的MA患者38例（男14例，女24例），MO患者44例（男15例，女29例），无头痛对照24例（男10例，女14例）。以肘前静脉注射手振生理盐水作为造影剂，并结合Valsaval动作，行经颅多普勒（TCD）监测，诊断PFO并对分流量进行分级。结果：MA组与对照组比，具有PFO者占42％，高于对照组的20％；其中中分流或大分流者高于对照组，差异有统计学意义。MO组具有PFO者也高于对照组，但差异无统计学意义。结论：MA患者比无头痛人群存在较多的PFO，其巾出现中分流或大分流的显著增多。

Migraine and Patent Foramen Ovale:A Contrast Transcranial Doppler Study

Aim:To investigate the frequency of patent foramen ovale (PFO) and median to large shunts in the cohort of migraine without aura (MO),migraine with aura (MA) and healthy people without headache in out- patient department.Methods:38 patients with MA ( 14 men,24 women),44 patients with MO ( 15 men,29 women), and 24 controls (10 men,14 women) were included in this study after informed consent.Clinical histories were carefully recorded.PFO was assessed with transcranial Doppler sonography with IV injection of agitated saline.A right-to-left shunt was graded according to the number of bubble signals in the transeranlal Doppler screen.Results: PFOs were shown in 16 patients of 38 patients with MA and only 5 cases in 24 controls.A median or large shunt was found in 9 patients with MAs and only 1 case in controls.The proportion of PFO in MA(42%) was higher than that in control(20%),especially was PFO with median or large shunt(P<0.05).Conclusion: Patients with MA have more PFO and larger right-to-left shunts of PFO than the group without headache.