| 抗雌激素活性化合物及其构效关系研究 |
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| 引用本文： | 吕波,王林,薛培凤. 抗雌激素活性化合物及其构效关系研究[J]. 国际药学研究杂志, 2010, 37(1): 16-20 |
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| 作者姓名： | 吕波 王林 薛培凤 |
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| 作者单位： | 100850,北京,军事医学科学院放射与辐射医学研究所七室;010059,呼和浩特,内蒙古医学院;军事医学科学院放射与辐射医学研究所七室,北京,100850;内蒙古医学院,呼和浩特,010059 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 抗雌激素疗法是雌激素受体依赖性乳腺癌内分泌疗法的重要手段之一。抗雌激素化合物按作用机制分类可分为选择性雌激素受体调节剂和纯抗雌激素剂,其结构类型主要包括取代雌二醇衍生物、三苯乙烯、苯骈杂环类及多酚类天然化合物。本文重点综述近年来抗雌激素化合物的作用机制、构效关系及其研究进展。
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| 关 键 词： | 雌激素受体 选择性雌激素受体调节剂 纯抗雌激素剂 构效关系 |
| 收稿时间： | 2009-11-09 |
| 修稿时间： | 2009-12-02 |
Studies on antiestrogen compounds and their structure-activity relationships |
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| LÜ, Bo,, WANG Lin,XUE Pei-feng. Studies on antiestrogen compounds and their structure-activity relationships[J]. Foreign Medical Sciences(Section of Pharmarcy), 2010, 37(1): 16-20 |
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| Authors: | LÜ Bo WANG Lin XUE Pei-feng |
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| Affiliation: | （1.Institute of Radiation Medicine,Academy of Military Medical Sciences, Beijing 100850, China;2.Inner Mongolla Medical College, Hohhot 010059, China） |
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| Abstract: | Antiestrogens have been proven to be highly effective in the treatment of estrogen receptor-dependent breast cancer. According to the mechanism,antiestrogen compounds were mainly categorized as selective estrogen receptor modulators (SERM)and pure antiestrogens, which structurally include estradiol derivatives, triphenylethylenes, benzo heterocyclic and polyphenol of natural compounds. The research advances on the antiestrogen compounds and their structure-activity relationships are reviewed. |
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| Keywords: | estrogen receptor selective estrogen receptor modulators pure antiestrogens structure-activity relationships |
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