Relationships of serum leptin to clinical and anthropometric findings in obese patients |
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Authors: | Adami Gian Franco Civalleri Dario Cella Franca Marinari Giuseppe Camerini Giovanni Papadia Francesco Scopinaro Nicola |
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Institution: | (1) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy;(2) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy;(3) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy;(4) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy;(5) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy;(6) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy;(7) Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy |
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Abstract: | Background: The authors evaluated the relationship between leptin and the clinical, anthropometric and metabolic variables
connected to the metabolic syndrome in obese individuals. Methods: A large group of patients with different degrees of obesity
was investigated: body mass index (BMI) values, serum leptin, fasting glucose and insulin, triglycerides and HDL-cholesterol
concentrations, insulin resistance index and blood pressure were measured. Results: On multiple regression analysis, serum
leptin levels appeared to be positively correlated to the BMI and to the serum HDL-cholesterol concentration. Principal component
factor analysis revealed three factors, explaining 61.3% of the total variance of the sample. General features of these factors
were: factor 1 - BMI values and serum leptin and fasting glucose concentration; factor 2 - systolic and diastolic blood pressure
and serum triglycerides and HDL-cholesterol concentration; factor 3 - fasting serum insulin concentration and insulin resistance
index. Conclusions: In obese subjects multiple factors underlie the metabolic syndrome and therefore more than one mechanism
may account for the clustering characteristics. In obese patients leptin loads only one factor, and therefore leptin does
not appear to be a key feature in the metabolic syndrome. On the contrary, multiple correlation and factor analysis data give
rise to the hypothesis that in obese patients, leptin may play a protective role against cardiovascular risk. |
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Keywords: | LEPTIN METABOLIC SYNDROME OBESITY MORBID OBESITY |
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