应用微刺激联合拮抗剂方案对76例卵巢低反应者进行体外受精-胚胎移植的临床研究

目的探讨微刺激联合拮抗剂方案进行体外受精一胚胎移植（ in vitro fertilization and embryo transfer, IVF - ET）在卵巢低反应患者的应用价值。方法对76例卵巢低反应患者采用微刺激联合拮抗剂方案进行IVF—ET的临床资料进行回顾性分析。结果76例卵巢低反应患者共116个起始周期，9个周期因提前排卵或无卵泡发育而取消，周期取消率为7．76％；共完成107个取卵周期，74个移植周期。获卵总数为251枚，平均获卵（2．69±1．62）枚。获取成熟卵母细胞204枚，总受精176枚，正常受精163枚，总受精率为70．12％，正常受精率为64．94％。卵裂163枚，卵裂率为92．61％。生化妊娠1例，临床妊娠12例，取卵周期临床妊娠率为11．21％，移植周期临床妊娠率为16．21％，起始周期临床妊娠率为10．34％。胚胎着床率为11．29％。结论微刺激联合拮抗剂方案可以作为使用常规控制性超排卵（controlled ovarian hyperstimulation,COH）方案进行过IVF—ET治疗失败的卵巢低反应者的另一有效治疗方案。

Clinical research of mini- stimulation combined with gonadotropin releasing hormone antagonist in 76 cases with poor ovarian responders In IVF- ET

Objective To explore the application worth of mini - stimulation combined with gonadotropin releasing hormone antagonist on 76 cases of poor ovarian responders in in vitro fertilization and embryo transfer （ IVF - ET）. Methods The data resulting from 76 cases of poor ovarian responders with IVF - ET in mini - stimulation combined with gonadotropin releasing hormone antagonist was analyzed retrospectively. Results 76 eases of poor ovarian responders underwent IVF treatment with 116 originate cycles. Oocyte retrievals were cancelled in 9 out of 116 cycles（7.76% ）. The total number of successful oocyte retrievals was 107. There was 74 embryo transfer peri- eds. The total number of ootid was 251 and the mean number of the ootid was （2. 69 ± 1.62）. The total number of mature egg cells was 204, of which 176 egg cells had to be fertilized（70. 12% ） and 163 eggs had to be normal - fertilized（64. 94% ）. 163 eggs had to be cleavaged（92.61% ）. One biochemistry pregnancy and twelve clinical pregnancies were obtained. The rate of obtained eggs cycle clinical pregnancy was 11.21%, the rate of transplant cycle clinical pregnancy wasl6.21%, the rate of originate cycle clinical pregnancy was 10.34%, the rate of embryo nidation was 11.29% . Conclusion Regimen of mini - stimulation combined with GnRH - antagonist was an easy and effective method for poor ovarian responders after one cycle of routine - controlled ovarian hyperstimulation schedule IVF - ET treatment.