欣母沛、葡萄糖酸钙和缩宫素联合预防剖宫产产后出血疗效观察

目的探讨欣母沛、10%葡萄糖酸钙和缩宫素联合应用预防剖宫产产后出血的效果。方法选取394例剖宫产患者随机分为3组,缩宫素组110例,卡孕栓组138例,欣母沛联合10%葡萄糖酸钙及缩宫素组（以下简称联合组）146例。测量各组剖宫产术中、术后2小时内及术后2～24小时出血量,分析各组之间的差异。结果测得剖宫产术中出血,缩宫素组（312.52±50.24）ml,卡孕栓组（270.38±72.15）ml,联合组（220.46±45.52）ml,联合组剖宫产术中出血量明显少于缩宫素组和卡孕栓组（P〈0.05）;测得剖宫产术后2小时内出血量,缩宫素组（183.36±47.53）ml,卡孕栓组（157.24±60.43）ml,联合组（103.35±72.54）ml,联合组剖宫产术后2小时内出血量明显少于缩宫素组和卡孕栓组（P〈0.05）;测得剖宫产术后2～24小时出血量,缩宫素组（96.21±45.53）ml,卡孕栓组（75.68±60.43）ml,联合组（68.57±72.58）ml,联合组剖宫产术后2～24小时出血量明显少于缩宫素组和卡孕栓组（P〈0.05）。结论欣母沛联合10%葡萄糖酸钙及缩宫素能更好地预防剖宫产术中及术后出血,且用药方便、安全、有效。

Clinical observation of the effects on prevention from postpartum hemorrhage after caesarean section by application of Hemabate combined with 10% of Calcium Gluconate and Oxytocin

Objective To study the effects on prevention of postpartum hemorrhage of caesarean section by application of Hemabate combined with 10% of Calcium Gluconate and Oxytocin.Methods Totally 394 cases of caesarean section were selected and randomly divided into Oxytocin group with 110 cases,Misoprostol group with 138 cases and Hemabate combined 10% Calcium gluconate and Oxytocin group（short for combination group）with 146 cases.The mean operative blood loss and amount of bleeding between 2 hours and 24 hours after delivery in three groups were measured respectively and compared.Results The mean operative blood loss in Oxytocin group and Misoprostol group and combination group were （312.52±50.24） ml,（270.38±72.15） ml,（220.46±45.52） ml respectively.The amount of the mean operative blood loss of combination group was significantly lower than those of Oxytocin group（P0.05） and Misoprostol group （P0.05）.The amount of bleeding of 2 hours after delivery in Oxytocin group,Misoprostol group and combination group were （183.36±47.53） ml,（157.24±60.43） ml,（103.35±72.54） ml respectively.The amount of bleeding of combination group was significantly lower than those of Oxytocin group（P0.05） and Misoprostol group（P0.05）.The amount of bleeding between 2 hours and 24 hours after delivery in Oxytocin group,Misoprostol group and combination group were （96.21±45.53） ml,（75.68±60.43） ml,（68.57±72.58） ml.The amount of bleeding of combination group was significantly lower than those of Oxytocin group （P0.05） and Misoprostol group （P0.05）.Conclusion Hemabate combined with 10% of Calcium Gluconate injection and Oxytocin was proved to be efficient in reducing the amount of intra-operative and post-operative hemorrhage that the operation of medicine was easy,safe and effective.