原发性骨质疏松症病人降钙素储备功能的改变

为进一步探讨降钙素（ＣＴ）在骨质疏松症发生中的作用，用钙负荷－降钙素兴奋试验观察２１例原发性骨质疏松症妇女ＣＴ储备功能的改变（血清ＣＴ用放射免疫分析法测定），并与４８名健康女性（其中绝经后妇女２０名）及７例骨量减少妇女进行比较。结果表明，未发生骨质疏松的健康绝经后妇女与绝经前妇女比较，血ＣＴ的基础值、峰值、升高幅度及曲线下面积均无明显差别；原发性骨质疏松症妇女以上４项指标均明显低于健康妇女，较骨量减少组妇女的血ＣＴ峰值、升高幅度亦有降低。而骨量减少组妇女与同年龄健康绝经后妇女比较，血ＣＴ的基础值和曲线下面积有所下降，但血ＣＴ峰值及升高幅度无差异。本研究未观察到绝经对ＣＴ储备功能有明显影响；骨质疏松病人的ＣＴ储备功能有降低，且降低程度与骨量丢失的程度有关，提示与骨质疏松本身似有内在联系，这种ＣＴ水平的降低可能参与了骨质疏松的发生。

CHANGES OF CALCITONIN RESERVE FUNCTION IN PATIENTS WITH PRIMARY OSTEOPOROSIS

In order to study the role of calcitonin (CT) in osteoporosis, the calcium loading calcitonin stimulated test (calcium element 3mg/kg body weight, i.v. 10min) was used to investigate calcitonin reserve function in 21 women with osteoporosis. The sesults were compared with those in 48 healthy women and 7 women with osteopenia. After calcium infusion, there was no significant difference in the basal CT, the peak CT value, the CT increase range, and the area under the curve (AUC) between pre and postmenopausal healthy women. In patients with primary osteoporosis, the four parameters were significantly lower than those in normal controls, and the CT peak value and increase range were lower than those in patients with osteopenia. In the osteopenia group, the basal CT value and its AUC were lower than those in the age matched control group, but no difference was found in the peak CT value and the increase range between the two groups. The results showed no evident effect of menopause on calcitonin reserve function, but suggested a possible relationship between the decrease of CT reserve function and osteoporosis in patients with osteoporosis. Calcitonin deficiency has something to do with the development of osteoporosis.