1-6二磷酸果糖对射频消融术所致心肌损伤的保护作用

目的:动态观察1-6二磷酸果糖(FDP)干预组及非干预组射频消融术(RFCA)前、后肌钙蛋白Ⅰ(cTnI)含量的变化,分析FDP对心肌损伤的保护作用。方法:对因室上性心动过速(除外冠心病,高血压等器质性心脏病)行RFCA的60例病人进行cTnI监测。对象随机分为FDP干预组与对照组。60例患者分别于RFCA前,RFCA后即刻、3、6、12、24、48 h各采静脉血1次,3 ml／次,分离血清,检测cTnI水平,并比较两组的差异。结果:FDP干预组在RFCA术后cTnI水平有所降低,6、12 h值与对照组cTnI值比较有显著差异(P<0.01)。结论:1-6二磷酸果糖对RFCA心肌损伤可能有一定的保护作用。

Protective effect of 1,6-Biphosphofructose against myocardial injury after radiofrequency current ablation

Objective: To observe the dynamic change of cTnI of 1, 6 - biphosphofructose treatment group and control group, after radiofrequency current ablation (RFCA). Methods: A total of 60 cases with paroxysmal supraventricular tachycardia undergoing RFCA were randomly divided into treatment group (n = 30) and control group (n=30). The treatment group was treated with 1,6 -biphosphofructose 500ml/d, While the control group was treated with glucose 500ml/d alone. A course of treatment in two groups all was 7 days. The levels of cTnI were measured before, and immediately, 3, 6, 12, 24, 48 h after RFCA. Results: The levels of cTnI in treatment group were significantly lower than that of control group (P<0. 01). Conclusion: The results show that the 1, 6 -biphosphofructose had protective effects against myocardial injury by RFCA.