| Protective effect of rhIL-1β on pancreatic islets of alloxan-induced diabetic rats |
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| 引用本文： | Wu LP,Chen LH,Zhang JS,Sun L,Zhang YQ. Protective effect of rhIL-1β on pancreatic islets of alloxan-induced diabetic rats[J]. World journal of gastroenterology : WJG, 2004, 10(22): 3353-3355. DOI: 10.3748/wjg.v10.i22.3353 |
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| 作者姓名： | Wu LP Chen LH Zhang JS Sun L Zhang YQ |
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| 作者单位： | [2]DepartmentofImmunology,theFourthMilitaryMedicalUniversity,Xi＇an710032,ShaanxiProvince,China [3]DepartmentofHistologyandEmbryology,theFourthMilitaryMedicalUniversity,Xi＇an710032,ShaanxiProvince,China [4]theSecondDepartmentofGeriatricsandGerontology,XijingHospital,FourthMilitaryMedicalUniversity,Xi＇an710032,ShaanxiProvince,China |
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| 基金项目： | 国家自然科学基金(项目编号：39870109) |
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| 摘 要： | AIM: To observe the protective effect of rhIL-1β on pancreatic islets of alloxan-induced diabetic rats. METHODS: Protection of rhIL-1β on pancreatic islets of alloxan-induced diabetic rats (n=5) was demonstrated with methods of immunohistochemistry and stereology. The concentration of serum glucose was measured by GOD method and that of serum insulin by RIA. RESULTS: The concentration of serum glucose increased but that of insulin decreased after administration of alloxan (150mg/kg), and the volume density and numerical density of the islets were zero. In rhIL-1β pretreated rats, although the concentration of serum insulin decreased (from 11.9±3.0mIU/L to 6.1±1.6mIU/L,P<0.05), that of glucose was at normal level compared with the control group. As compared with alloxan group, the concentration of serum glucose in rhIL-1β pretreated rats decreased (from 19.4±8.9mmol/L to 12.0±4.0mmol/L, P<0.05) and the volume density increased(0/L to. 1/L, P<0.05). CONCLUSION: rhIL-1β pretreatment may have protective effect on the islets of alloxan-induced diabetic rats.
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| 关 键 词： | 保护作用 rhIL-1β 胰岛疾病 四氧嘧啶 诱发作用 糖尿病 老鼠 葡萄糖代谢 |
| 收稿时间： | 2003-11-04 |
Protective effect of rhIL-1beta on pancreatic islets of alloxan-induced diabetic rats |
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| Wu Li-Ping,Chen Li-Hua,Zhang Jin-Shan,Sun Lan,Zhang Yuan-Qiang. Protective effect of rhIL-1beta on pancreatic islets of alloxan-induced diabetic rats[J]. World journal of gastroenterology : WJG, 2004, 10(22): 3353-3355. DOI: 10.3748/wjg.v10.i22.3353 |
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| Authors: | Wu Li-Ping Chen Li-Hua Zhang Jin-Shan Sun Lan Zhang Yuan-Qiang |
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| Affiliation: | Second Department of Geriatrics and Gerontology, Xijing Hospital, Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, Shaanxi Province, China. |
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| Abstract: | AIM: To observe the protective effect of rhIL-1beta on pancreatic islets of alloxan-induced diabetic rats. METHODS: Protection of rhIL-1beta on pancreatic islets of alloxan-induced diabetic rats (n = 5) was demonstrated with methods of immunohistochemistry and stereology. The concentration of serum glucose was measured by GOD method and that of serum insulin by RIA. RESULTS: The concentration of serum glucose increased but that of insulin decreased after administration of alloxan(150 mg/kg), and the volume density and numerical density of the islets were zero. In rhIL-1beta pretreated rats, although the concentration of serum insulin decreased (from 11.9+/-3.0 mIU/L to 6.1+/-1.6 mIU/L, P<0.05), that of glucose was at normal level compared with the control group. As compared with alloxan group, the concentration of serum glucose in rhIL-1beta pretreated rats decreased (from 19.4+/-8.9 mmol/L to 12.0+/-4.0 mmol/L, P<0.05) and the volume density increased(0/L to. 1/L, P<0.05). CONCLUSION: rhIL-1beta pretreatment may have protective effect on the islets of alloxan-induced diabetic rats. |
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