| 降压通脉方对自发性高血压大鼠血压及左心室肥厚的影响 |
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| 引用本文： | 王亚红,肖文君,罗斯琼,王琛,韩俊阁,尚涛,王刚,郭维琴,王硕仁.降压通脉方对自发性高血压大鼠血压及左心室肥厚的影响[J].中华中医药杂志,2010(3). |
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| 作者姓名： | 王亚红 肖文君 罗斯琼 王琛 韩俊阁 尚涛 王刚 郭维琴 王硕仁 |
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| 作者单位： | 北京中医药大学东直门医院中医内科学教育部重点实验室;北京市崇文区第一人民医院;北京市东城区社区卫生服务中心; |
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| 基金项目： | 国家自然科学基金资助项目(No.30572460)~~ |
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| 摘 要： | 目的:探讨降压通脉方控制血压、逆转高血压左心室肥厚的作用。方法:以自发性高血压大鼠(SHR)为高血压及高血压左心室肥厚模型,随机分为降压通脉方组、卡托普利组、空白对照组;并以WKY大鼠为正常对照组。检测大鼠尾动脉收缩压(SBP)、大鼠左室质量(LV)、左心室质量指数(LVMI)、左室壁相对厚度。结果:与模型组比较,中药组于药后第4周出现血压下降,降压效果于第14周达到与西药相比无明显差异。模型组、中药组、西药组LVMI较正常组明显升高,提示左室肥厚形成,中药组、西药组左室壁相对厚度较模型组室壁薄,提示降压通脉方有逆转左室肥厚的作用。结论:降压通脉方可有效地降低SHR血压,有一定逆转SHR左心室肥厚的作用。
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| 关 键 词： | 高血压 左心室肥厚 动物实验 降压通脉方 |
Effects of Jiangya Tongmai Formula on blood pressure and left ventricular hypertrophy of spontaneous hypertensive rats |
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| WANG Ya-hong,XIAO Wen-jun,LUO Si-qiong,WANG Chen,HAN Jun-ge,SHANG Tao,WANG Gang.Effects of Jiangya Tongmai Formula on blood pressure and left ventricular hypertrophy of spontaneous hypertensive rats[J].China Journal of Traditional Chinese Medicine and Pharmacy,2010(3). |
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| Authors: | WANG Ya-hong XIAO Wen-jun LUO Si-qiong WANG Chen HAN Jun-ge SHANG Tao WANG Gang |
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| Institution: | Director:GUO Wei-qin1;WANG Shuo-ren1;1Department of Cardiovascular;Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine;Beijing 100700;China;2The First People's Hospital of Chongwen District;Beijing 100075;3Community Hygiene Service Centre of East-city District;Beijing 100011;China |
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| Abstract: | Objective:To study the effect of Jiangya Tongmai Formula on blood pressure and left ventricular hypertrophy(LVH)of spontaneous hypertensive rats(SHR).Methods:Taking SHR for animal model of hypertension and LVH,divided then into 4 groups at random:distilled water group,Jiangya Tongmai Formula group,Captopril group,control group and WKY rats were used as a normal group.The SBP of arteria caudilis,left ventricular mass index(LVMI),the weigh of LV,and trans-diameter of cardiomyocyte(TDM)on sections of the left ... |
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| Keywords: | Hypertension Left ventricular hypertrophy Experimental study Jiangya Tongmai Formula |
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