| Acetylcholine Transmission in Nucleus Accumbens and VTA on Heroin- Seeking Elicited by Contextual and Conditioned Cues |
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| 引用本文： | Wenhua Zhou Huifen Liu Fuqiang Zhang Suien Tang Huaqiang Zhu Miaojun Lai Peter W. Kalivas Guodong Yang. Acetylcholine Transmission in Nucleus Accumbens and VTA on Heroin- Seeking Elicited by Contextual and Conditioned Cues[J]. 中国药理通讯, 2005, 22(4): 56-57 |
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| 作者姓名： | Wenhua Zhou Huifen Liu Fuqiang Zhang Suien Tang Huaqiang Zhu Miaojun Lai Peter W. Kalivas Guodong Yang |
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| 作者单位： | [1]Laboratory of Behavioral Neuroscience, Ningbo AddictionResearch and Treatment Center, 42 Xibei Str. , Ningbo 315010 [2]Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina29425 |
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| 摘 要： | The involvement of cholinergic transmission in heroin self - administration and the reinstatement of heroin - seeking was examined in rats trained to nose - poke for intravenous heroin. Systemic treatment with physostigmine modestly reduced the acquisition and rate of heroin self-administration. Following 10 -14 days of self-administration, rats were left in the home environment for 14 days. Withdrawn animals were evaluated for context-induced nosepokes during the first hour after being returned to the self-administration apparatus. One hr later a conditioned stimulus （ house light, light in the nose-poke hole, sound of the infusion pump） was presented to initiate cue-induced reinstatement.
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| 关 键 词： | 乙酰胆碱 VTA 吗啡依赖 血管疾病 药物治疗 |
Acetylcholine Transmission in Nucleus Accumbens and VTA on Heroin- Seeking Elicited by Contextual and Conditioned Cues |
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| Wenhua;Zhou;Huifen;Liu;Fuqiang;Zhang;Suien;Tang;Huaqiang;Zhu;Miaojun;Lai;Peter;W.;Kalivas;Guodong;Yang. Acetylcholine Transmission in Nucleus Accumbens and VTA on Heroin- Seeking Elicited by Contextual and Conditioned Cues[J]. , 2005, 22(4): 56-57 |
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| Authors: | Wenhua Zhou Huifen Liu Fuqiang Zhang Suien Tang Huaqiang Zhu Miaojun Lai Peter W. Kalivas Guodong Yang |
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| Abstract: | |
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| Keywords: | reinstatement heroin self-administration relapse extinction Acetylcholine |
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