Regulation of cytokine production in the bone marrow during postcytostatic regeneration by SC-1+ and Thy-1+ cells |
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| Authors: | A. M. Dygai E. Yu. Sherstoboev E. D. Gol'dberg |
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| Affiliation: | (1) Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, USSR |
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| Abstract: | The role of SC-1+ and Thy-1+ cells in the regulation of interleukin-3 production and erythropoietic and colony-stimulating activity of bone marrow cells is studied in cyclophosphamide-treated mice. It is shown that elimination of SC-1+ and Thy-1+ cells has no effect on the production of these cytokines during the early postcytostatic period and upregulates production of some factors stimulating proliferation and colony-formation in the spleen. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 4, pp. 374–377, April, 1998 |
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| Keywords: | T cell precursors cytokines Cytostatic treatment |
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