CUSHING'S SYNDROME WITH BILATERAL MULTINODULAR ADRENAL HYPERPLASIA |
| |
| Authors: | Tamiko Takemura Yoshinobu Eishi Shigeru Hatakeyama Yuji Takahashi |
| |
| Affiliation: | Department of Pathology, Japanese Red Cross Medical Center, Tokyo;Department of Pathology, Tokyo Medical &Dental University, Tokyo;Department of Surgery, Japanese Red Cross Medical Center |
| |
| Abstract: | An unusual case of Cushing's syndrome of a 59-year-old man with bilateral multinodular adrenal hyperplasia and microadenoma of the pituitary gland is presented. Failure to suppress plasma Cortisol with large doses of dexamethasone may suggest autonomous growth of hyperplastic nodules of the adrenals, which were at first induced by prolonged stimuli of ACTH from the microadenoma of the pituitary gland. ACTH could not be detected in the microadenoma cells on paraffin sections, while Crooke's cells were strongly positive for ACTH. The interrelation between bilateral multinodular adrenal hyperplasia and pituitary microadenoma is discussed. |
| |
| Keywords: | |
|
|
