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1 780例自然流产患者的细胞遗传学分析
引用本文:钱卫平,谭玉梅,宋丹,谭跃球,卢光琇. 1 780例自然流产患者的细胞遗传学分析[J]. 中南大学学报(医学版), 2005, 30(3): 258-260
作者姓名:钱卫平  谭玉梅  宋丹  谭跃球  卢光琇
作者单位:深圳市罗湖医院生殖医学中心,深圳,518001;中南大学生殖与干细胞工程研究所,长沙,410078;深圳市罗湖医院生殖医学中心,深圳,518001;中南大学生殖与干细胞工程研究所,长沙,410078
基金项目:国家自然科学基金(30170480,30470884)
摘    要:目的:探讨染色体异常与不良妊娠史的关系,为生殖中心自然流产病例的遗传咨询和产前诊断提供指导。 方法:培养淋巴细胞,常规收获制片,G显带处理,必要时加做C带分析,对1780例具有妊娠24周前自然流产史的患者进行染色体核型分析。结果:共发现染色体异常57例,异常率为3.20%。其中平衡易位23例,罗氏易位14例,复杂易位3例,其它17例。流产1次、2次与流产3次及以上者,其染色体异常率频率分别为1.7%,2.3%和5.8%。结论:在自然流产病例的染色体异常中,染色体易位是主要类型。染色体异常检出率随着自然流产次数的增加而有升高的趋势。流产3次以上群体中,染色体异常频率明显增加。

关 键 词:自然流产  染色体易位  核型
文章编号:1672-7347(2005)03-0258-03
收稿时间:2005-05-14
修稿时间:2005-05-14

Cytogenetic study of 1780 cases of spontaneous abortion
QIAN Wei-ping,TAN Yu-mei,SONG Dan,TAN Yue-qiu,LU Guang-xiu. Cytogenetic study of 1780 cases of spontaneous abortion[J]. Journal of Central South University. Medical sciences, 2005, 30(3): 258-260
Authors:QIAN Wei-ping  TAN Yu-mei  SONG Dan  TAN Yue-qiu  LU Guang-xiu
Affiliation:1.Reproductive Medical Center, Luohu Hospital,Shenzhen 518001, China; 2.Institute of Reproduction andStem Cell Engineering,Central South University, Changsha 410078, China
Abstract:OBJECTIVE: To explore the relationship between chromosome anomaly and spontaneous abortion, and to provide useful information for genetic counseling and prenatal diagnosis in reproductive clinic. METHODS: A total of 1 780 patients who had a history of spontaneous abortion before 24 weeks of gestation were enrolled. The lymphocyte culture and harvest were performed according to standard methods. Karyotypes were analyzed by G-banding in all cases and C- banding in some cases in addition. RESULTS: Altogether 57 abnormal karyotypes were found and the overall incidence of chromosomal abnormalities was 3.20% (women 3.32%; men 2.12%). Among them 23 cases were the balanced translocation; 14 cases were the Robertsonian translocation, 3 cases were the complex chromosomal rearrangement, and the other 17 cases were the other abnormalities. In women with 1, 2, 3 or more spontaneous abortion, the incidence of chromosomal abnormalities was 1.7%, 2.3%, and 5.8%, respectively. CONCLUSION: Translocations are the major abnormal karyotpes associated with spontaneous abortions. The chance of finding chromosomal aberration increases with the number of abortions. Chromosomal abnormalities are more common in women with 3 or more spontaneous abortions.
Keywords:spontaneous abortion  translocation  karyotypes
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