| Fas Bax和bcl-2蛋白在银屑病病人表皮细胞中的表达 |
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| 引用本文： | 刘振祥,杨雪琴.Fas Bax和bcl-2蛋白在银屑病病人表皮细胞中的表达[J].中国皮肤性病学杂志,1999,13(1):6-7. |
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| 作者姓名： | 刘振祥 杨雪琴 |
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| 作者单位： | [1]北京医科大学第三医院皮肤产 [2]北京空军总医院皮肤科 |
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| 摘 要： | 目的观察银屑病病人表皮细胞凋亡中凋亡基因Ｆａｓ、Ｂａｘ（ｂ ｃｅｌ相关基因）和凋亡抑制基因ｂｃｌ ２（Ｂ ｃｅｌＬｙｍｐｈｏｍａ／Ｌｅｕｋｅｍｉａ２）的作用及其相互关系。方法采用免疫组化染色法在３３例银屑病皮损标本中，观察了Ｆａｓ、Ｂａｘ及ｂｃｌ ２蛋白的表达。结果发现３３例银屑病皮损标本中，Ｆａｓ２９例阳性表达；Ｂａｘ２３例阳生；３３例ｂｃｌ ２表达皆阴性。５例正常对照中，Ｆａｓ及Ｂａｘ皆阴性，ｂｃｌ ２在基底层细胞中阳性。结论结果提示Ｆａｓ和Ｂａｘ蛋白的高表达、ｂｃｌ ２的不表达与银屑病损害中表皮细胞凋亡增多有关。
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| 关 键 词： | 银屑病 蛋白质Fas 蛋白质Bax 蛋白质bcl |
Expression of Fas Bax and bcl 2 in the Epidermal Cells of Psoriatie Lesions. |
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| Liu Zhenxiang,Li Shiyin,Yang Xueqin,et al..Expression of Fas Bax and bcl 2 in the Epidermal Cells of Psoriatie Lesions.[J].The Chinese Journal of Dermatovenereology,1999,13(1):6-7. |
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| Authors: | Liu Zhenxiang Li Shiyin Yang Xueqin |
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| Institution: | Liu Zhenxiang,Li Shiyin,Yang Xueqin,et al.Department of Dermatology,The Third Hospital of Beijing Medical University,Beijin,100083 |
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| Abstract: | Objective To investigate the role of apoptosis gene Fas,Bax,bcl 2,and the relationship between them in the apoptosis of psoriatic epidermal cells.Method Using immunohistochemical staining for Fas,Bax,and bcl 2 expression in 33 cases of psoriasis.Result In 33 biopsies of skin lesions of psoriasis we found Fas posifive in 29 cases,Bax positive in 23 cases,bcl 2 negative in all ceses.In 5 cases of normal confrol,both Fas and Bax were negative bcl 2 was positive in the basal cell layer.Conclusion The result sugested that the expression of Fas,Bax,and no expression of bcl 2 are relatel to the apoptosis of epidermal cells in psoriatic lesions. |
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| Keywords: | Psoriasis Protein Fas Protein Bax Protein bcl 2 |
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