Renal transplantation in children under 5 years of age |
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Authors: | J A Kari Jacopo Romagnoli Patrick Duffy Oswald N Fernando Lesley Rees Richard S Trompeter |
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Institution: | (1) Renal Unit, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK Tel.: +44-171-813-8346, Fax: +44-171-829-8841, GB |
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Abstract: | Between March 1987 and December 1997, 59 renal transplants 49 cadaveric, 10 live related (LRD)], were performed in 54 children
aged 5 years and younger. Six children required a second transplant. The median (range) age of the recipients was 2.9 (1.4–5.0)
years; mean weight was 12.6 kg (7.4–23) and donor age 11 (2–50) years. Immunosuppression was cyclosporin or FK506, prednisolone,
and azathioprine. Antithymocyte globulin was given as induction therapy for second transplants. Patient survival was 98.3%;
1 patient died from upper gastrointestinal haemorrhage. Graft survival was 67.7% at 1 year, 57.4% at 5 years, and 45.2% at
10 years. No LRD graft was lost during 7 years of follow-up. Thrombosis was the main cause of graft loss (10 cases) followed
by vascular rejection (2 cases). There was no significant difference in graft survival between recipients aged less than 2,
2–3, and 3–5 years. The height standard deviation score (±SD) improved from –2.1±1.3 at transplantation to –1.0±1.3 at 1 year,
–1.1±1.5 at 5 years, and to –0.14±1.1 at 10 years.
Received: 19 August 1998 / Revised: 18 November 1998 / Accepted: 18 November 1998 |
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Keywords: | Transplantation Donor age Recipient age Thrombosis Growth |
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