成纤维细胞在炎症反应中具有“岗哨细胞”的作用

长期以来人们认为成纤维细胞的作用只是维持组织结构和参与损伤修复,是一种比较惰性的细胞。但近年来的研究令人惊喜地发现;成纤维细胞与淋巴细胞相似,也是具有异质性和组织特异性的细胞群,而且也能被细菌产物、损伤组织释放的产物及促炎细胞因子等激活。激活的成纤维细胞可出现新的功能,如产生细胞因子和暂时性地合成并分泌趋化因子,招引调动白细胞杀灭细菌,启动炎症反应等,因此被称为“岗哨细胞”（ｓｅｎｔｉｎｅｌ ｃｅｌｌｓ）。此外,成纤维细胞还能产生前列腺素,调节免疫细胞活性及控制细胞外基质的合成。由于许多组织中都…

Fibroblasts function as "sentinel cell" in inflammatory reaction

The fibroblasts have long been considered as structural elements and playing a main role in wound healing. Recent studies indicated that fibroblasts are heterogenic cells and function as resident sentinel cells in inflammatory reaction. When activated by substances released during tissue injury or derived from infectious microorganisms or by proinflammatory cytokines, tissuespecific fibroblasts can transiently produce certain chemokines and initiate a cascade of inflammatory reaction. In addition fibroblasts can produce prostanoids that participate in inflammatory and immune responses. In this review, the new role of fibroblasts in regulation of inflammation and immune reactions and possible molecular mechanism will be discuss.