| Abstract: | Eighty-eight clomiphene citrate-resistant infertile patients with oligomeno-rrhoea or amenorrhoea attributable to polycystic ovarian disease were divided at random into three groups. Twenty-nine patients were treated with ovarian electrocautery, 30 with human menopausal gonadotropins (hMG) and 29 with pure follicle stimulating hormone (FSH). Successful ovulation was induced in 71-4, 70-6 and 66-7% of the cycles in the groups respectively. Ten patients conceived after electrocautery and pure FSH therapy while 15 conceived after hMG medication (chi-squared = 1 -6464, P = 0–439). The six-cycle cumulative pregnancy rate in the three consecutive groups was 521, 55-4 and 38-3%. Four further pregnancies were achieved after treating 10 patients in the electrocautery group with clomiphene citrate (100 mg/day for 5 days) for 25 cycles. The rate of pregnancy wastage in the corresponding groups was 21-4, 53-3 and 40% (chi-squared = 3–127, P = 0–2039). Ovarian electrocautery is equally effective as hMG and pure FSH in the treatment of PCO patients resistant to clomiphene citrate therapy. |
