PSE在肝癌合并脾功能亢进患者中的辅助治疗作用

目的探讨脾动脉部分栓塞联合肝动脉栓塞化疗对肝癌合并脾功能亢进治疗的临床意义。方法 2005年1月～2009年12月间在我院对43例肝癌合并脾亢的患者进行脾动脉部分栓塞联合肝动脉栓塞化疗,脾脏栓塞面积50%～70%。栓塞前后测定血细胞数量,并作配对t检验。结果脾动脉部分栓塞术后1个月的白细胞和血小板均较术前明显升高(t=11.315,P=0.000;t=11.486,P=0.000),术后出现发热、腹痛、呕吐等并发症,未出现脾脓肿等严重并发症。结论脾动脉部分栓塞术能有效提高白细胞及血小板数量,缓解脾功能亢进,有助于肝癌治疗正常进行。

Adjunctive Therapeutic Role of Partial Splenic Embolizaition in Hepatocarcinoma and Hypersplenism

Objective To explore the adjunctive therapeutic role of partial splenic embolizaition （PSE） in liver cancer and hypersplenism. Methods First partial splenic embolization and then transcatheter hepatoarterial chemoembolization （THC） were operated on 43 cases of hepatocarcinoma and hypersplenism in our hospital from Jan.2005 to Dec.2009,and the splenic embolization area was 50% to 70%. The changes of blood cells before and after embolization were detected and compared. Paired-samples t test was used for statistical analysis. Results The levels of leucocyte and platelet were obviously improved one month after PSE （t=11.315, P=-0.000; t=-11.486, P=0.000）.After the operation,febrile,abdominal pain and vomiting occurred but no spleen abscess and other serious complications appeared. Conclusion PSE is an effective method for increasing the levels of leucocyte and platelet and can relieve hypersplenism, which is helpful for the consecutive THC in liver cancer.