轻度认知功能障碍的临床干预研究

目的探讨老年轻度认知功能损害(MCI)患者的干预治疗。方法治疗组MCI患者33例,给予多奈哌齐5mg/d,共12个月,同期空白对照组27例。分析各组向痴呆转化率以及MMSE、MOCA和ADL变化。结果多奈哌齐组较对照组简易智能状态检测量表(MMSE)评分显著改善(P0.05),蒙特利尔认知量表(MOCA)评分改善更为明显(P0.01),日常生活自理量表(ADL)评分改善不明显。由MCI向AD转化率、服用和未服用多奈哌齐组于12个月时分别为9.1%和14.8%(P0.05)。结论多奈哌齐能有效改善轻度认知功能损害(MCI)患者的认知功能,推迟MCI向AD转化。

Clinical Intervention in Mild Cognitive Impairment

Objective To detect the treatment in agedness with Mild cognitive impairment （MCI）. Methods 33 patients of MCI in experiment group given Donepezil per day for 12 months, and 27 patients in blank group. The rate of conversion from MCI to dementia, measured with the Mini- mental state examination（MMSE）, Montreal Cognitive Assessment（MOCA） and Activities of Daily living Scale（ADL）, is compared between the two groups. Results The grades of Mini-mental state examination （MMSE）are improved in experiment group than that in controlled group（P〈0.05）. The grades of Montreal cognitive assessment（MOCA）is also improved in experiment group than that in controlled group （P〈0.01）.But the grades of Activities of daily living scale （ADL） is not improved in experiment group than that in controlled group （P〉 0.05）.The rate of conversion from MCI to dementia drop by 9.1% and 14.8% in 12 months among pations with or without donepezil. Conclusion Donepezil can efectively improve the cognized function in the patients with MCI and postpone the conversion of MCI to dementia.