复方乳酸依沙吖啶散中乳酸依沙吖啶含量测定方法研究

目的：探讨复方乳酸依沙吖啶散中乳酸依沙吖啶含量的测定方法。方法排除影响乳酸依沙吖啶吸光度值的因素，筛选出供试液制备的最佳方法：减少取样量，采用微孔滤膜于80℃以下条件下加压过滤。采用紫外分光光度法在362 nm处测定吸光度（A），计算乳酸依沙吖啶含量。结果乳酸依沙吖啶在5~22.5 mg/L（r=0.9997）范围内线性关系良好，高、中、低含量样品（n=5）平均测定率分别为93.132%、93.074%和93.261%。结论该方法简单、快速，测定结果符合要求，可作为复方乳酸依沙吖啶散中乳酸依沙吖啶含量的测定方法。

Discussion on Content Determination of Ethacridine Lactate in Compound Ethacridine Lactate Powder

Objective To discuss the content determination of Ethacridine Lactate in Compound Ethacridine Lactate Powder. Methods The best preparation method of reducing the amount of sample and pressuring filter with mi-cropore film below 80℃ was screened by excluding the interference factors. The absorbance （ A） and content were detec-ted at 362 nm with UV spectrophotometry. Results The Ethacridine Lactate had good linear relationship during 5 -22. 5 mg/L （r=0. 9997） of linear range. The average detection rates of samples with high, middle and low contents （n=5） were 93. 132%, 93. 074% and 93. 261% respectively. Conclusion The method is simple, quick and feasi-ble, and can be used to detect the content of Ethacridine lactate in Compound Ethacridine Lactate Powder.