小剂量卡维地洛治疗慢性心力衰竭的疗效观察

目的:探讨小剂量卡维地洛治疗慢性心力衰竭的疗效。方法:90例慢性心力衰竭患者被随机分为两组:卡维地洛组(45例,在原有治疗的基础上加用卡维地洛,起始剂量为3.125mg,2次/d,持续两周,无不良反应则加至6.25mg,2次/d,直到6个月)。对照组(45例,进行常规治疗)。分别检测两组患者治疗前后心率(HR),左室射血分数(EF),左室舒张末期内径(LVDED),左室收缩末期内径(LVESD),心胸比例及心功能变化。结果:与常规治疗组相比卡维地洛组患者的HR变慢,LVEF增加,LVDED,LVESD及心胸比减少,心功能改善(P<0.05～<0.01),总有效率达91%。结论:卡维地洛治疗慢性心功能不全能安全、有效。

Therapeutic effect of carvedilol in patient with chronic congestive heart failure

Objective:To study the therapeutic effect of carvedilol in patient with chronic congestive heart failure(CHF).Methods:The 90 CHF patients were randomly divided into carvedilol group(45 cases,treated with carvedilol of six months based routine therapy)and control group(45 cases,treated with routine therapy of six months).The indexes of heart function of two groups were compared.Results:Compared with control group the heart rate decreased,left ventricular ejection fraction increased,left ventricular end-systolic dimension,left ventricular end-diastolic dimension and ratio of cardiac-chest decreased(P<0.05~<0.01)in carvedilol group.The total effective rate of carvedilol group was 71%.Conclusion:Carvedilol treatment for CHF patients is effect and safe.