| 帕罗西汀治疗阿尔茨海默病的抑郁对照研究 |
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| 引用本文： | 任清涛,刁艳云,耿国绪. 帕罗西汀治疗阿尔茨海默病的抑郁对照研究[J]. 临床精神医学杂志, 2004, 14(2): 90-91 |
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| 作者姓名： | 任清涛 刁艳云 耿国绪 |
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| 作者单位： | 1. 255100,山东淄博市第五人民医院
2. 山东淄博市沂源县土门医院 |
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| 摘 要： | 目的：比较帕罗西汀与氯米帕明在阿尔茨海默病(AD)抑郁症状治疗中的疗效和不良反应。方法：帕罗西汀组51例，氯米帕明组44例，均诊断为AD，汉密顿抑郁量表(HAMD，17项)≥18分。比较两组患者治疗后的HAMD减分率，采用副反应量表(TESS)评定不良反应。结果：帕罗西汀组与氯米帕明组总体疗效相当，但帕罗西汀组起效较快，不良反应发生率低。结论：帕罗西汀在AD抑郁症状治疗中具有一定优势，值得临床推广应用。
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| 关 键 词： | 帕罗西汀 氯米帕明 阿尔茨海默病 抑郁 |
| 文章编号： | 1005-3220(2004)02-0090-02 |
| 修稿时间： | 2003-06-19 |
A comparative study between paroxetine and clomipramine in the treatment of depression in Alzheimer disease |
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| REN Qing-tao,DIAO Yan-yun,GENG Guo-xu. A comparative study between paroxetine and clomipramine in the treatment of depression in Alzheimer disease[J]. Journal of Clinical Psychological Medicine, 2004, 14(2): 90-91 |
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| Authors: | REN Qing-tao DIAO Yan-yun GENG Guo-xu |
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| Affiliation: | REN Qing-tao,DIAO Yan-yun,GENG Guo-xu.The fifth People's Hospital of Zibo,Shandong 255100 |
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| Abstract: | Objective:To compare the efficacy and security of paroxetine and clomipramine in the treatment of depression in Alzheimer disease(AD). Method:Ninty-nine patients with depression in AD were divided into treating group with paraxetine( n =51) and controlled group with clomipramine( n =44).Clinical progress was examined with HAMD-17 and TESS. Results:The overall effective rates of paroxetine group and clomipramine group were 98.0% and 95.5% respectively. No remarkable differences in the efficacy was found between two groups.But paroxetine had fewer adverse events and took effects more quickly. Conclusion:In the tratment of depression in Alzheimer disease,Paroxetine is an efficacious drug,with mild side effects. |
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| Keywords: | Paroxetine Clomipramine Alzheimer disease Depression |
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