| 睾酮诱导小鼠形成条件性位置偏爱和雌激素受体相关 |
| |
| 引用本文： | 钱介庵,刘鸿宇,翟海峰.睾酮诱导小鼠形成条件性位置偏爱和雌激素受体相关[J].中国药物依赖性杂志,2013(3):188-190,196. |
| |
| 作者姓名： | 钱介庵 刘鸿宇 翟海峰 |
| |
| 作者单位： | 中北大学运动医学研究所;北京大学中国药物依赖性研究所 |
| |
| 基金项目： | 国家自然科学基金(30873051,81271473) |
| |
| 摘 要： | 目的:研究雌激素受体与睾酮诱导小鼠条件性位置偏爱的关系。方法:通过皮下注射睾酮训练小鼠形成条件性位置偏爱;在注射睾酮前注射雌激素受体拮抗剂ICI182780和他莫西芬,通过观察睾酮条件性位置偏爱的变化来判断雌激素受体是否在其中起作用。结果:0.5、1、2 mg.kg-1睾酮训练12 d,可以诱导小鼠产生条件性位置偏爱。雌激素受体拮抗剂ICI182780(2 mg.kg-1)或他莫西芬(1 mg.kg-1)可以抑制睾酮诱导的小鼠条件性位置偏爱。结论:睾酮具有奖赏效应,雌激素受体可能参与睾酮的奖赏效应。
|
| 关 键 词： | 睾酮 雌激素受体 条件性位置偏爱 |
ESTROGEN RECEPTOR IS RELATED TO TESTOSTERONE - INDUCED PLACE PREFERENCE IN MICE |
| |
| QIAN Jiean,LIU Hongyu,ZHAI Haifeng.ESTROGEN RECEPTOR IS RELATED TO TESTOSTERONE - INDUCED PLACE PREFERENCE IN MICE[J].Chinese Journal of Drug Dependence,2013(3):188-190,196. |
| |
| Authors: | QIAN Jiean LIU Hongyu ZHAI Haifeng |
| |
| Institution: | 1(Institute of Sport and Exercise Medicine,North University of China,Taiyuan,030051) 2(National Institute on Drug Dependence,Peking University,Beijing,100191) |
| |
| Abstract: | Objective: To explore the relationship between estrogen receptor(ER) and testosterone-induced conditioned place preference(CPP) in mice.Methods: Subcutaneous injection of testosterone was used to build up CPP in mice.Two ER antagonists,ICI182780 and tamoxifen,were administrated 30 min prior to testosterone to detect the requirement of ER activation in formation of testosterone CPP.Results: Testosterone at the dose range of 0.5,1,2 mg.kg-1 induced significant CPP in mice in a 12-day training procedure.ICI182780(2 mg.kg-1) and tamoxifen(10 mg.kg-1) could decrease testosterone CPP.Conclusion: Testosterone has reward property in mice,and estrogen receptor may play a role in the reward of testosterone. |
| |
| Keywords: | testosterone estrogen receptor conditioned place preference |
| 本文献已被 CNKI 等数据库收录！ |
|
