| 抗凋零基因bcl－2在反应性淋巴组织中的免疫组织化学定位 |
| |
| 引用本文： | 陈协群,王文亮,黄高升. 抗凋零基因bcl－2在反应性淋巴组织中的免疫组织化学定位[J]. 医学争鸣, 1996, 0(2) |
| |
| 作者姓名： | 陈协群 王文亮 黄高升 |
| |
| 作者单位： | 第四军医大学西京医院血液科，第四军医大学病理学教研室 |
| |
| 摘 要： | 采用免疫组织化学ＰＡＰ技术探讨了抗细胞凋零基因ｂｃｌ－２在反应性淋巴组织中的表达与分布．结果Ｂｃｌ－２蛋白主要定位于淋巴结与扁桃体中的淋巴滤泡套区、脾脏白髓淋巴小结以及胸腺髓质的长寿命淋巴细胞中，表明Ｂｃｌ－２蛋白介导的细胞凋零障碍可能参与调控Ｂ或Ｔ淋巴细胞依赖的免疫反应过程．
|
| 关 键 词： | 凋零，bcl－2基因，淋巴组织，免疫组织化学 |
Immunohistochemical localization of anti-apoptosis gene bcl-2 in physiological lymphoid tissues |
| |
| Chen Xiequn,Wang Wenliang,Huang Gaosheng. Immunohistochemical localization of anti-apoptosis gene bcl-2 in physiological lymphoid tissues[J]. Negative, 1996, 0(2) |
| |
| Authors: | Chen Xiequn Wang Wenliang Huang Gaosheng |
| |
| Abstract: | Immunohistochemical PAP technique was applied to investigate the expression and distribution of anti-apoptosis gene bcl-2 in physiological lymphoid tissue.The results showed that Bcl-2 protein was mainly distributed in the long-lived lymphocytes restricted in follicular mantles of lymph nodes and tonsils,nodules of white pulp of spleens and thymus medullae.These data indicate that Bcl-2-mediated inhibitory effect on apoptosis may implicate in modulating immune response process dependent on B-or T-cell. |
| |
| Keywords: | apoptosis bcl-2 gene lymphoid tissue immunohistochemistry |
| 本文献已被 CNKI 等数据库收录！ |
