| 酒石酸唑吡坦原料药的多晶型问题研究 |
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| 引用本文： | 吴建敏,李慧义,岳志华,张莉. 酒石酸唑吡坦原料药的多晶型问题研究[J]. 中国药事, 2007, 21(11): 892-893 |
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| 作者姓名： | 吴建敏 李慧义 岳志华 张莉 |
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| 作者单位： | 1. 中国药品生物制品检定所,北京,100050
2. 中国医学科学院中国协和医科大学药物研究所 |
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| 摘 要： | 采用红外光谱、差示扫描量热法和粉末X射线衍射技术等研究酒石酸唑吡坦原料药的多晶型问题。采用三种方法得到的图谱均显示酒石酸唑吡坦原料药存在多晶型问题,且不同企业生产的样品混晶比例存在一定差异。
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| 关 键 词： | 酒石酸唑吡坦 多晶型 红外光谱 差示扫描量热法 粉末X射线衍射 |
| 文章编号： | 1002-7777（2007）11-0892-02 |
Studies on Polymorphism of Zolpidem Tartrate Subtances |
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| Wu Jianmin,Li Huiyi,Yue Zhihua,Zhang Li. Studies on Polymorphism of Zolpidem Tartrate Subtances[J]. Chinese Pharmaceutical Affairs, 2007, 21(11): 892-893 |
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| Authors: | Wu Jianmin Li Huiyi Yue Zhihua Zhang Li |
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| Affiliation: | National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050; Institute of Materia Medica, Chinese Academy of Medical Sciences |
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| Abstract: | Polymorphism of zolpidem tartrate was studies by IR spectrometry, differential scanning calorimetry and X-ray powder diffraction, the results showed that zolpidem tartrate substances from different pharmaceutical factories all exhibiting polymorphism and the content of every crystal in the substances is different. |
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| Keywords: | zolpidem tartrate polymorphism IR spectrometry differential scanning calorimetry X-ray powder diffraction |
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