| 糖皮质激素对兔炎症过程中中性粒细胞粘附的影响 |
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| 引用本文： | 陈骏,龚肖崎.糖皮质激素对兔炎症过程中中性粒细胞粘附的影响[J].中华医学杂志,1995,75(5):270-272. |
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| 作者姓名： | 陈骏 龚肖崎 |
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| 作者单位： | 第二军医大学病理生理教研室 |
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| 摘 要： | 为了探讨糖皮质激素在分子水平抑制炎症过程中中性粒细胞粘附的作用机理，分别测定了兔中性粒细胞ＣＤ１８的表达以及中性粒细胞与ＩＣＡＭ－１包被磁珠的粘附率，并对两者进行相关性分析。
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| 关 键 词： | 糖皮质激素 炎症 细胞粘连 嗜中性白细胞 |
The effects of glucocorticoid on rabbit polymorphonu-clears during inflammation |
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| Chen Jun,
Gong Xiaoqi,Zhong,Jigen..The effects of glucocorticoid on rabbit polymorphonu-clears during inflammation[J].National Medical Journal of China,1995,75(5):270-272. |
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| Authors: | Chen Jun Gong Xiaoqi Zhong Jigen |
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| Institution: | Department of Pathophysiology. SecondMilitary Medical University.
Shanghai 200433 |
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| Abstract: | he CD18 expression on rabbit polymorphonuclears(PMNs) and
adhesion rate of rabbit PMNs to ICAM-1coated magnetic beads were determined, and the
corre-lationship was analysed between CD18 expression andadhesion rate. The results showed
that glucocorticoidinhibited the rise of CD18 expression on rabbit PMNscaused by tumor
necrosis factor (TNF) and that the in-hibrtory effect reversed when glucocorticoid receptor(GR)
was blocked by RU 38486. There was a positivecorrelationship (r = 0. 966) after PMNs were
culturedwith a range concentration of dexamethasone (Dex ).The data indicate that GC inhibites
the rise of CD18 ex-pression on rabbit PMNs caused by TNF which is medi-ated by GR, and
plays an important role in inhibition ofPMNs adhesion. |
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| Keywords: | inflammation Cell adhesionPolymorphonuclears Glucocorticoids |
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