Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers |
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| Authors: | Anny Fortin Roger K. Verbeeck Frans H. Jansen |
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| Affiliation: | (1) Dafra Pharma R&D bvba, Slachthuisstraat 30/7, 2300 Turnhout, Belgium;(2) Louvain Drug Research Institute, Catholic University of Louvain, Brussels, Belgium;(3) Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa |
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| Abstract: | Objective The aim of the present study was to compare the pharmacokinetic properties, bioavailability and tolerability of artesunate (AS) and amodiaquine (AQ) administered as a fixed-dose combination (Amonate FDC tablets; Dafra Pharma, Turnhout, Belgium) or as a non-fixed dose combination of separate AS tablets (Arsuamoon; Guilin Pharmaceutical Co, Shanghai, China) and AQ tablets (Flavoquine; Sanofi-Aventis, Paris, France). |
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