E2F-1及相关蛋白在子宫内膜癌中的表达及其相关性研究 |
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引用本文: | 周海霞,李燕辉,时志民,王蕾,司军英,吴彩花,范建. E2F-1及相关蛋白在子宫内膜癌中的表达及其相关性研究[J]. 中国医学装备, 2013, 0(10): 86-88 |
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作者姓名: | 周海霞 李燕辉 时志民 王蕾 司军英 吴彩花 范建 |
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作者单位: | 1. 邯郸市中西医结合医院 河北 邯郸 056002 2. 河北工程大学医学院病理科 河北 邯郸 056001 3. 邯郸市中心医院妇产科 河北 邯郸 056001 4. 邯郸市传染病医院妇产科 河北 邯郸 056002 |
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基金项目: | 河北省教育厅自然科学青年基金(Q2012095)“子宫内膜肿瘤转录因子E2F及相关因素病理生理意义的研究” |
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摘 要: | 目的:检测子宫内膜癌组织中转录因子E2F-1和Ki-67表达情况,并探讨其在子宫内膜癌中的意义。方法:采用免疫组织化学S-P法检测60例子宫内膜癌和32名正常子宫内膜组织中的表达。结果:子宫内膜癌组织中E2F-1和Ki-67表达定位于细胞核,其阳性表达率分别为58.33%(35/60)和85.00%(51/60),明显高于正常子宫内膜组织0和12.5%(4/32)(X^2=27.71,X^2=42.63;P〈0.05)。两者的表达与淋巴结转移、临床病理分期有关(x^2=5.79,X^2=8.28,X^2=11.77,X^2=4.04IP〈0.05),在子宫内膜癌组织中E2F-1和Ki-67两者之间比较表达无明显相关性。结论:E2F-1和Ki-67在子宫内膜癌呈高表达,且与子宫内膜癌的发生、发展和转移密切相关。
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关 键 词: | 子宫内膜肿瘤 E2F-1 Ki-67 免疫组化 |
Research on the expression and significance of E2F-1 and Ki-67 in endometrial carcinoma |
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Affiliation: | ZHOU Hai-xia, LI Yan-hui, SHI Zhi-min, et al Handan Central Hospital, Handan 056002, China. |
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Abstract: | Objective: To determine the expression of E2F-1 and Ki-67 in the endometrial carcinoma and the significance. Methods: To detect the expressions of E2F-1 and Ki-67 in 60 cases of endometrial cancer and 32 cases of normal endometrial tissue by immunohisto chemistry S-P. Results: The expressions of E2F-1 and Ki-67 were located with the cytoplasm. The positive expression rates were 58.33% (35/60) and 85.00% (51/60) which were significantly higher than that in normal endometrial tissue in 0, 12.5%(4/32)(x:= 27.71, x2= 42.63, P〈 0.05). Both of their expressions were related with lymph nodemetastasis, clinical stage and pathological staging(x^2= 5.79, x^2 = 8.28, x^2 = 11.77, x^2 = 4.04, P 〈 0.05). In endometnal carcinoma, theexpressons of E2F-1 and Ki-67 were negatively correlated with each other. Conclusion: E2F-1 and Ki-67 were highly expressed in the endometrial cancinoma and their expressions were related with endometrial carcinoma the development and the metastasis. |
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Keywords: | Endometrial carcinoma E2F-1 Ki-67 Immunohistochemistry |
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