超敏C反应蛋白及胱抑素C联合检测对早期糖尿病肾损伤的临床价值

目的探讨超敏C反应蛋白（hs-CRP）及血清胱抑素C（CysC）在2型糖尿病（T2DM）早期肾损伤诊断中的应用价值。方法根据尿肾功能指标（包括尿微量白蛋白（mAlb）、血清肌酐（SCr））把130例T2DM患者分为尿、肾功能正常组及尿、肾功能异常组各65例。并选择同期65例健康查体者做对照组。分别测定3组CysC、hs-CRP、Cr及尿mAlb水平。结果2型糖尿病患者hs-CRP及CysC的水平高于对照组，尿肾功异常组显著高于尿肾功正常组，且hs-CRP和CysC水平呈正相关。结论 hs-CRP及CysC可作为糖尿病肾病早期诊断的灵敏指标，联合检测更具有临床实用价值。

The Clinical Significance of Combined Measuring of High Sensitivity c-reactive Protein and Serum Cystatin C in Early Renal Damage in Diabetes Mellitus

Objective To explore the clinical diagnostic value of the Combined measuring of high sensitivity C-reactive protein and serum cystatin C in type 2 diabetic mellitus（T2DM）patients with early renal injury. Methods According to urine renal function indice（including urinary microalbumin and serum creatinine）,130 patients with T2DM were divided into Two groups：urine renal function normal group（n=65） and urine renal function abnormal group（n=65）. 65 healthy patients were served as control group. The levels of serum hs-CRP, Cys C, Cr and urinary malb were measured. Results The levels of serum hs-CRP and Cys C in patients with T2DM were higher than those in control group（P〈0.01）;while the levels of serum hs-CRP and Cys C in urine renal function abnormal group were signiifcantly increased than those in urine renal function normal group（P〈0.01）.Hs-CRP was positively correlated with serum Cys C.Conclusion Hs-CRP and Cys C can be used as sensitive indice of diagnosing early renal damage in type2 diabetic mellitus.Combined measuring had more practical value.