| 核苷类药物治疗乙型肝炎肝硬化失代偿疗效观察 |
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| 引用本文： | 郑素静.核苷类药物治疗乙型肝炎肝硬化失代偿疗效观察[J].医学理论与实践,2011,24(2):130-131. |
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| 作者姓名： | 郑素静 |
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| 作者单位： | 天津市蓟县人民医院传染科,301900 |
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| 摘 要： | 目的:观察核苷类药物治疗乙型肝炎肝硬化失代偿期的疗效。方法:对48例乙型肝炎肝硬化失代偿期患者随机分组,所有患者在保肝对症治疗的基础上,分别给予拉米夫定(A组)100mg/d、阿德福韦酯(B组)10mg/d口服,疗程为48周,同时设立保守治疗组(C组),观察所有患者临床症状、体征、肝功能变化、凝血酶原时间活动度(PTA)、HBV-DNA定量、HBeAg/HBeAb转换情况。结果:通过抗病毒治疗,A、B两组患者无1例死亡,临床表现、肝功能、PTA均有明显改善,C组疗效最差,死亡2例,抗病毒治疗组与保守治疗组疗效有显著差异(P<0.01)。结论:乙型肝炎肝硬化失代偿期患者应行抗病毒治疗,可首先选用拉米夫定或阿德福韦酯。
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| 关 键 词： | 肝硬化 失代偿 抗病毒治疗 |
Effect of Nucleoside Drugs in Treating the Liver Decompensation of Hepatitis B Cirrhosis |
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| ZHENG Sujing.Effect of Nucleoside Drugs in Treating the Liver Decompensation of Hepatitis B Cirrhosis[J].The Journal of Medical Theory and Practice,2011,24(2):130-131. |
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| Authors: | ZHENG Sujing |
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| Institution: | ZHENG Sujing.Department of Infectious Diseases,the People's Hospital of Ji Country,Tianjin City 301900 |
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| Abstract: | Objective:To observe the effect of nucleoside drugs in treating the liver decompensation of hepatitis B cirrhosis.Methods:Forty-eight patients with hepatitis B cirrhosis of the liver decompensation were divided into three groups(A,B,C).All were treated in a basic treatment.A and B group were given by lamivudine(100mg/d)and adefovir(10mg/d) respectively.C group was a control.The course lasted 48 weeks.The clinic symptoms,change of liver function,PTA,quantitative HBV-DNA,HBeAg/HBeAb transformation were observ... |
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| Keywords: | Cirrhosis The liver decompensation Antiviral treatment |
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