克林霉素致昏迷

1例53岁男性患者,因咽炎给予克林霉素600 mg溶入0.9%氯化钠注射液250 ml静脉滴注.滴注结束时,患者突然昏迷,呼之不应,呼吸12次/min,双侧瞳孔对光反射消失.给予吸氧、补液治疗1 h后仍呈深昏迷状态.分别给予甘露醇、呋塞米、纳洛酮、葛根素、奥扎格雷钠等静脉滴注,治疗约12 h患者清醒,治疗约15 h时突然出现狂躁,给予氟哌啶醇5 mg肌内注射.治疗约20 h患者精神状态基本恢复正常.

Clindamycin-induced coma

A 53-year-old male patient with pharyngitis was given an IV infusion of clindamycin 600 mg dissolved in 0.9% sodium chloride 250 ml.After infusion completion,the patient developed a coma and unresponsiveness to verbal stimuli.His respiratory rate was 12 breaths/min and his pupils showed no light reflex.He received oxygen inhalation therapy and fluid supplement and,one hour later,he remained in a deep coma.The patient was treated with mannitol,furosemide,naloxone,puerarin and sodium ozagrel by intravenous in...