| 肠炎冲剂调节胃肠功能及止泻作用的动物实验研究 |
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| 引用本文： | 丁海峰,曹永兵,刘洪涛,牟斌,姜远英.肠炎冲剂调节胃肠功能及止泻作用的动物实验研究[J].药学服务与研究,2011,11(1):30-33. |
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| 作者姓名： | 丁海峰 曹永兵 刘洪涛 牟斌 姜远英 |
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| 作者单位： | 第二军医大学药学院药理学教研室 |
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| 基金项目： | 上海市中药现代化重大专项基金资助项目 |
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| 摘 要： | 目的:研究肠炎冲剂对实验动物胃肠功能的影响及其止泻作用。方法:通过肠炎冲剂对大鼠正常小肠以及小鼠推进机能亢进小肠运动的影响,家兔离体十二指肠平滑肌解痉实验和大鼠胃排空实验,研究肠炎冲剂对小鼠、大鼠和家兔胃肠功能的影响。通过番泻叶和蓖麻油致小鼠腹泻实验,研究肠炎冲剂对小鼠的止泻作用。结果:肠炎冲剂能抑制大鼠正常小肠及推进机能亢进小鼠的小肠推进运动,对家兔离体十二指肠平滑肌自发活动及氯化乙酰胆碱所致肠痉挛均有显著抑制作用。胃排空实验中,肠炎冲剂对胃内残留率无明显影响。肠炎冲剂能显著缓解番泻叶诱发的小鼠腹泻。结论:肠炎冲剂具有肠道调节功能,对番泻叶所致腹泻有一定的抑制作用。本研究为肠炎冲剂的临床应用提供了理论依据。
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| 关 键 词： | 肠炎冲剂 胃肠活动 小肠推进实验 解痉实验 胃排空实验 |
The effect of Changyan granules on gastrointestinal function and its anti-diarrhea action in experimental animals |
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| DING HaiFeng,CAO YongBing,LIU HongTao,MU Bin,JIANG YuanYing.The effect of Changyan granules on gastrointestinal function and its anti-diarrhea action in experimental animals[J].Pharmaceutical Care and Research,2011,11(1):30-33. |
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| Authors: | DING HaiFeng CAO YongBing LIU HongTao MU Bin JIANG YuanYing |
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| Institution: | DING HaiFeng,CAO YongBing,LIU HongTao,MU Bin,JIANG YuanYing(Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
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| Abstract: | Objective:To investigate the effects of Changyan granules on gastrointestinal function and its anti-diarrhea action in experimental animals.Methods:Effects of Changyan guanules on gastrointestinal function were evaluated in small intestine propulsion test in normal rats and the small intestine with excessive movement in mice,antispasmodic test of isolated duodenum smooth muscle of rabbits and gastric emptying test in rats.Anti-diarrhea effect was also evaluated in the diarrhea models of mice induced by cast... |
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| Keywords: | Changyan granules gastrointestinal movement small intestine propulsion test antispasmodic test gastric emptying test |
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