| 盐酸格拉司琼巴布剂基质处方设计 |
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| 引用本文： | 柳正青,胡晋红,朱全刚,刘继勇. 盐酸格拉司琼巴布剂基质处方设计[J]. 中国新药杂志, 2006, 15(17): 1467-1470 |
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| 作者姓名： | 柳正青 胡晋红 朱全刚 刘继勇 |
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| 作者单位： | 第二军医大学附属长海医院药学部,上海,200433 |
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| 摘 要： | 目的：采用正交设计法对格拉司琼巴布剂基质处方进行优化。方法：通过正交设计，以影响巴布剂物理性状的几种主要辅料为考察因素，以各种辅料不同用量为考察水平，以成型巴布剂基质的快黏力和内聚力为指标，通过对数据的分析，优选出最佳的基质配方。结果：优化的基质配方为部分中和聚丙烯酸钠．氢氧化钙．聚乙烯吡洛烷酮-甘油（1：0．15：4：4）。结论：优化处方具有良好的涂展性、保湿性，且黏着力适中。
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| 关 键 词： | 巴布剂 基质处方 正交设计 盐酸格拉司琼 |
| 文章编号： | 1003-3734（2006）18-1467-04 |
| 收稿时间： | 2006-03-01 |
The matrix components of granisetron hydrochloride (GRN) cataplasma formulation |
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| LIU Zheng-qing,HU Jin-hong,ZHU Quan-gang,LIU Ji-yong. The matrix components of granisetron hydrochloride (GRN) cataplasma formulation[J]. Chinese Journal of New Drugs, 2006, 15(17): 1467-1470 |
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| Authors: | LIU Zheng-qing HU Jin-hong ZHU Quan-gang LIU Ji-yong |
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| Affiliation: | Department of Pharmacy, Changhai Hospital, The Second Medical University of Shanghai, Shanghai 200433, China |
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| Abstract: | Objective: To optimize the matrix components of granisetron hydrochloride (GRN) cataplasma formulation. Methods; Four matrix agents were compared based on the several physicochemi-cal indexes including adhesion force and cohesive force. Subsequently, the matrix components of GRN cataplasma were optimized by means of orthogonal design. Results; The optimal proportion of the matrix components was made from partial neutralization sodium polyacrylate: calcium hydroxide: polyvinylpyrroli-done: glycerin (1:0. 15:4=4) , which showed moderate viscosity with good spreadable and humectant capacities. Conclusion; The optimal formulation of CRN cataplasma was attainable. |
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| Keywords: | cataplasma matrix formulation orthogonal design granisetron hydrochloride |
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