胰腺癌螺旋断层调强放疗剂量学分析

目的：分析胰腺癌螺旋断层调强放疗（HelicalTomotherapy，HT）靶区剂量和危及器官受量，给临床医生选择合适的照射剂量提供依据。方法：对13例进行螺旋断层调强放疗的胰腺癌病人靶区剂量分布和危及器官的进行回顾行分析，探讨剂量实施的合理性。结果95％和100％的处方剂量覆盖的临床靶区（CTV）体积分别平均为99．03％和95．69％．CTV适形指数（CI）和靶区剂量均匀指数（HI）分别平均为0．81±0．10和1．08±0．02。放疗计划中十二指肠的V30、V20、V10分别平均为11．91±6．46％、32．56±23．14％、62．49±22．57％，右肾的V20、V10分别平均为12．09±12．05％、35．82±2．96％，左肾的V30、V20和V10分别为2．05±1．80％、12．79±8．42％和29．56±16．56％，脊髓最大受量平均为28．02±2．96Gy，胃的V30、V20和V10平均受量为10．08±4．93％、20．28±8．51％和35．03±24．11％。结论：胰腺癌螺旋断层调强放疗在给予靶区根治剂量的同时，能有效地降低危及器官的高剂量区，并把危及器官的照射剂量限制在耐受剂量以下。

To Analyze Dosemitry in Helical Tomotherapy For Pancreas Carcinoma

objective： To analyze dose of target and organs at risk during the helical tomotherapy （HT）for for pancreas carcino- ma. Methods： The retrospective review enrolled 13 pancreas carcinoma patients treated with HT and had,evaluate target vol- umn dose distribute and spare normal tissue.Results： CTV had good CI, HI, separately was 0.81 ±0.10,1.08±0.02. The V100,V95 of CTV were 95.69±0.03%,99.03±0.05%.The V30,V20 and V10 of duodenum were 11.91±6.46%,32.56±23.14% and 62.49±22.57% .The V30 V20 and V10 of left kidney were 2.05±1.80% , 1 2.79±8.42%and 29.56±16.56%. The V20 and V10 of right kid- ney were 12.09±12.05% and35.82±2.96%.The V30,V20 and V10 of stomach were 10.08 ±4.93% ,20.28±8.51% and 35.03± 24.11% .The Dr and V20 of spinal cord were 28.02±14.09 and 4567±22.34. Conclusions： HT can reduce the high dose volume and be better protect the organ at risks ,can enhance the dose of target volume.