Effect of the rat estrous cycle at ovariectomy on striatal D-1 dopamine receptors |
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Authors: | D Lévesque T Di Paolo |
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Institution: | School of Pharmacy, Laval University, Québec, Canada. |
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Abstract: | We have investigated the effect of the surgical suppression of gonadal steroid hormones by ovariectomy on striatal D-1 dopamine (DA) receptors, in relation with the stage of the estrous cycle at the time of surgery. Plasma levels of 17 beta-estradiol and progesterone declined rapidly to a minimum one and two days after ovariectomy, respectively. Ovariectomy of female rats in proestrus led to an increased density of striatal D-1 DA from the first to the fourth day following surgery with a return to control values on the 7th day. Rats ovariectomized (OVX) in estrus showed an increased striatal D-1 DA receptor density from the second to the fourth day following surgery with a return to control values 7 days following ovariectomy. Striatal D-1 DA receptor density of rats OVX in diestrus remained constant up to 7 days after surgery. The affinity of striatal D-1 DA receptors remained unchanged in all cases. Therefore, this report illustrates that steroid hormonal fluctuations as occurring during the 4-day estrous cycle of the rat can modulate striatal D-1 DA receptors. |
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