| 大川芎速释微丸体外溶出度测定 |
| |
| 引用本文： | 李军晨,杨辉,郑琴,杨明,王芳,谢乔,万小莉.大川芎速释微丸体外溶出度测定[J].江西中医学院学报,2010,22(4):34-36. |
| |
| 作者姓名： | 李军晨 杨辉 郑琴 杨明 王芳 谢乔 万小莉 |
| |
| 作者单位： | 1. 江西中医学院药学院,南昌,330004
2. 现代中药制剂教育部重点实验室,南昌,330004 |
| |
| 基金项目： | "十一五"重大新药创新:中药新型给药系统技术平台 |
| |
| 摘 要： | 目的：对大川芎速释微丸中阿魏酸进行了溶出度测定,以考察其内在质量。方法：应用桨法,以高效液相色谱法测定大川芎速释微丸中阿魏酸的含量为指标,对大川芎速释微丸中阿魏酸进行了溶出度测定。结果：以蒸馏水为溶出介质,转速为75 r/min,经30min溶出度为标示量的85%以上;阿魏酸的线性范围为0.508～35.56μg/ml（r=0.998 8）,平均回收率为97.057%（RSD=2.04%）,3批样品溶出度相似。结论：所用方法灵敏、准确、快速,能有效监控本品质量。
|
| 关 键 词： | 高效液相色谱法 大川芎速释微丸 阿魏酸 溶出度 |
Studies on the Dissolution of Da Chuan Xiong Immediate-release Pellets in Vitro |
| |
| LI Jun-chen,YANG Hui,ZHENG Qin,YANG Ming,WANG Fang,XIE Qiao,WAN Xiao-li.Studies on the Dissolution of Da Chuan Xiong Immediate-release Pellets in Vitro[J].Journal of Jiangxi College of Traditional Chinese Medicine,2010,22(4):34-36. |
| |
| Authors: | LI Jun-chen YANG Hui ZHENG Qin YANG Ming WANG Fang XIE Qiao WAN Xiao-li |
| |
| Institution: | LI Jun-chen , YANG Hui , ZHENG Qin, YANG Ming, WANG Fang , XIE Qiao , WAN Xiao- li( 1. Jiangxi Univesity of Traditional Chinese Medieine,Nangchang 330004; 2. Key Laboratory of Modern Preparation f Traditional Chinese Medicine, Nangchang 330004) |
| |
| Abstract: | Objective：To establish the dissolution determination method of Da Chuan Xiong immediate-release pellets. Methods： HPLC method was developed for the determination of isofroxiti the dissolution of Da Chuan Xiong immediate-release pellets. Results： The paddle method was applied to calculate dissolution with distilled waters as solvent and rotation speed of 75 r/min. The method showed a good linear relationship in the range of 0.508 - 35. 56μg/ml（ r = 0.998 8 ）. The average recovery was 97.06% （ RSD = 2.04% ）. The dissolutions of 3 batches of samples were all above 85% in 30 minutes. Conclusion： The method is simple, accurate and reliable for the determination of the dissolution of Da Chuan Xiong immediate-release pellets. |
| |
| Keywords: | HPLC Da Chuan Xiong immediate-release pellets Femlic acid dissolution |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
