纤维介素在硬皮病血管病变中的表达

目的 探讨纤维介素在硬皮病血管病变中的作用。方法 运用免疫组织化学方法检测20例硬皮病患者和10例正常人皮肤组织连续切片中的纤维介素和纤维蛋白。结果 病变血管的内皮细胞及血管周围巨噬细胞和淋巴细胞内可见多量纤维介素表达，呈胞膜型和浆膜型；在纤维介素阳性区域均发现有不同程度的纤维蛋白沉积，微血栓处出现多量纤维蛋白沉积。结论 在硬皮病血管病变机制中，可能存在纤维介素介导的免疫凝血途径的影响。

The expression of Fibrinogen-like protein 2(hfgl2) in vasculopathy of scleroderma

Objective To study the function of Fibrinogen-like protein 2(hfgl2) in the vasculopathy of scleroderma. Methods With the method of immunohistochemstry, to detect hfgl2 and fibrin in the serial sections of the skin tissue in 20 patients with scleroderma and 10 normal cases. Results It was seen the increased expression of hfgl2 in the endothelial cells of the affected vessels and in the perivascular macrophages and lymphocytes, which were presented as cell membrane type and plasma membrane type. The fibrin depositions with different degrees were found in hfgl2-positive area. Increased fibrin deposition was seen in microthrombus. Conclusion There might be the effect of hfgl2-mediated immuno-coagulation path in the pathogenesis of vasculopathy of scleroderma.