Inositol stimulates DNA and protein synthesis, and expansion by rabbit blastocysts in vitro. |
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Authors: | M M Fahy M T Kane |
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Affiliation: | Department of Physiology, University College, Galway, Ireland. |
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Abstract: | The effect of different concentrations (0, 0.6, 3, 15, 75 and 375 microM) of myo-inositol on the development of rabbit morulae to expanded blastocysts was investigated in terms of blastocyst expansion and synthesis of DNA and protein, as measured by incorporation of [3H]thymidine and [14C]amino acids into acid-precipitable material. A concentration of 15 microM inositol caused a 2.8-fold increase in blastocyst expansion (P less than 0.01), a 9.9-fold increase in thymidine incorporation into DNA (P less than 0.01) and a 3.6-fold increase in amino acid incorporation into protein (P less than 0.01). There were no significant differences in the range from 15 to 375 microM inositol. |
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Keywords: | rabbit/inositol/blastocyst/DNA/protein |
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