四合一口服液治疗痰热壅肺证实验研究

目的：探讨四合一口服液对小儿痰热壅肺证的作用机制。方法：观察四合一口眼液对实验动物免疫功能的影响及其抗病毒及诱生干扰素、防治呼吸窘迫综合征、治疗呼吸道合胞病毒感染等作用。结果：四合一口服液能提高实验性小鼠特异及非特异免疫功能，诱生干扰素及白细胞介素-2，并有抑制病毒、肺炎链球菌、乙型链球菌等呼吸道病原体的作用，对油酸所致兔呼吸窘迫综合征的肺部病理改变及呼吸道合胞病毒感染BALB／C小鼠有一定保护作用。结论：四合一口服液能提高免疫功能，促进诱生干扰素，对呼吸道病毒有抑制作用，可防治呼吸窘迫综合征，这可能是其治疗小儿痰热壅肺证的作用机制之一。

Experimental Study on Siheyi Oral Liquid for Retention of Heat－ Phlegm in the Lung

Objective: To explore the mechanisms of Siheyi Oral Liquid on treating the Retention of Heat - Phlegm in the Lung of children. Methods: To observe the effect of Siheyi Oral Liquid on the immunologic function of experimental animals, and the function of resisting virus and inducing IFN, preventing ADRS, treating the infections by RSV, and so on . Results: Siheyi Oral Liquid could inhance the specific and nonspecific immunologic function, induce the IFN and IL- 2, and have the use of inhibiting the pathogem of respiratory viruses, streptococcus pheumoniae, beta streptococcus and so on . It could protect the tissue damage in the lung of the rabbits induced by oleic and the BALBLC rats infected by RSV. Conclusion: Siheyi Oral Liquid can inhance the immulogical function, induce IFN, inhibit the virus of respiratory, prevent the ARDS. It may be one of the machanism of treating the retention of Heat - Phlegm in the Lung of children.