Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia |
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| Authors: | Dessing Mark C de Vos Alex F Florquin Sandrine van der Poll Tom |
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| Affiliation: | Center for Experimental and Molecular Medicine, Room F0-117, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. m.c.dessing@amc.uva.nl |
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| Abstract: | To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality. |
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